TRPV3 is a master regulator of skin homeostasis, genetically validated in human disease – Olmsted Syndrome.

Molecular Damage

In certain diseases and conditions, an imbalance in TRPV3 leads to an excessive entry of Ca²⁺ into the cells. This, in turn, impairs the skin structure and function and may lead to uncontrolled growth of the skin epidermis, increased inflammation and itch sensation.